Dr Saloni Sethi, Dr Aditi Arora, Dr Vikash Kumari Kasana, Dr Premlata Mital, Dr Ishita Agarwal, Dr Isha Ramneek, Dr Sakshi Bansal
During pregnancy calcium demand increases due to increase requirement by the developing foetus. This demand is met by dietary calcium intake. Physiological changes in pregnancy tend to lower calcium and calcium homeostasis is maintained by various hormones. The present study was done to find association of sociodemographic factors of the pregnant women with hypocalcaemia.
Material and methods: 100 women in their third trimester of pregnancy were included in the study after obtaining written informed consent. After detail history and examination, 5 ml venous blood is collected to measure serum ionic calcium. Data were entered in to MS Excel sheet and analysed.
Results: Normal serum ionic calcium range is 4.2 – 5.5 mg%. Out of 100 women 36% women had hypocalcaemia. There was no significant association between hypocalcaemia and age (p=0.8), residence (p=0.6), religion (p=0.1), socio-economic status (p=0.8). There was significant association between hypocalcaemia and literacy status (p-0.02). Women with past history of preterm birth and abortion had more risk of having hypocalcaemia. There was a negative correlation between maternal age and mean serum ionic calcium level.
Conclusion: Hypocalcaemia is common in pregnancy. Hypocalcaemia was more common in women who were above 25 years of age, muslim, illiterate, belonging to lower and middle socio-economic status and multiparous. Risk of hypocalcaemia was more in women with gestational age below 34 weeks. All women in their antenatal period should be screened for hypocalcaemia and calcium should be supplemented routinely to all women during antenatal period.
Keywords: Hypocalcaemia, pregnancy, socio-demographic factors
Ashutosh kumar Yadav, Reetu, Shashank Tiwari, Nitin Rajan*
Posaconazole, a novel triazole antifungal medication, shares the same active mechanism as other azoles by inhibiting lanosterol-14a-demethylase, a key enzyme involved in ergosterol synthesis. This mechanism is effective against most fungi, except Pneumocystis and Pythium. Posaconazole exhibits a strong affinity for this target due to its distinct chemical structure, which allows it to combat even modified forms of fluconazole and voriconazole. It is widely distributed in the body, with a particular affinity for the liver, and has shown excellent tolerance in long-term studies. Adverse events associated with posaconazole treatment are generally mild and include minor gastrointestinal and neurological complaints. Posaconazole has demonstrated promising clinical efficacy in treating fungal infections that are often resistant to existing therapies, such as aspergillosis, fusariosis, and emerging Zygomycosis. Common side effects reported during posaconazole treatment include fever, diarrhea, nausea, vomiting, and headaches. Clinical trials have also noted elevated liver enzyme levels, hyperbilirubinemia, and hepatocellular damage, indicating the importance of monitoring these parameters during posaconazole therapy. This review aims to consolidate current knowledge on Posaconazole’s pharmacokinetics, pharmacodynamics, toxicity, resistance, clinical experience in specialized populations, and novel treatment strategies to provide a comprehensive understanding of the drug\\\'s clinical utility.
KEYWORDS: Mucormycosis, Posaconazole, Zygomycosis, Fluconazole, Voriconazole
Dr. Maheshkumar Nilkanth Chaudhari
Abstract –
Ayurveda &Yoga is a key to enhancing India’s status as Vishwa Guru. Yoga and Ayurvedaare two inseparable branches of life science, that stem from the Vedas. Only these both sciences are medical sciences on the earth, who thinks not only a physical body but also Mind & Spirit. Ayurveda, the science of life is one of the ancient and comprehensive systems of health care. Quest for good health and long life is probably as old as human existence. According to Indian philosophy, health is prerequisite to pursue materialistic, social and spiritual upliftment of human being. It is believed that Lord Brahma, the creator of the universe was also the first preacher of Ayurveda.The proactive efforts made by India in positioning the Ayurveda and Yoga as the soft power of India and at the same time generating evidence about the health benefits as well as safety of these systems has given significant boost to demand of Ayurveda and Yoga.Bharat has a long history and strong base of Ayurveda which is gaining the attention of international community& this will definitely help to make Bharat as Vishwa-Guru. The health promotive, disease preventive and curative roles of Ayurveda with its holistic approach are the reasons for its acceptance. Based on sound concept and practices, AyurvedSystem of Medicine is well documented, experienced & not experimented as modern medicine, that’s why it is called ‘Tailor made medicine’. Ayurveda’s Fundamental principles are eternal, never be changed. Ideal treatment according to Ayurveda is one which cures the disease without causing adverse effect.
