ALUMINUM TOXICITY: A VALIDATION USING LIPID PEROXIDATION AS A BIOCHEMICAL PARAMETER.
- Department of Human Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, NnamdiAzikiwe University P.M.B 5001, Nnewi Campus, Anambra State, Nigeria. Postal code: 435001.
- Department of Biochemistry, Faculty of Biological Sciences, University of Nigeria, Nigeria.
Toxicity of aluminum using lipid peroxidation product – Malondialdehyde (MDA) concentration in serum, liver and brain homogenates in male Wistar albino rats was investigated in this study. A total of eighteen (18) rats of six (6) each in a group were administered 0.38 and 38 mg/kg body weight aluminum while the control group received 0.2ml normal saline for seven and fourteen days respectively. The results from this study show that MDA concentrations were significantly higher (p<0.05) and non-significantly higher (p>0.05) in 38mg/kg and 0.38mg/kg in serum, liver and brain homogenates after 7 and 14 days of aluminum treatment. However, the MDA concentration was highest in the brain homogenate. The results suggest lipid peroxidation probably due to the generation of free radicals, though need to be investigated further.
Department of Human Biochemistry, Faculty of Basic Medical Sciences, College of Health Sciences, Nnamdi Azikiwe University P.M.B 5001, Nnewi Campus, Anambra State, Nigeria. Postal code: 435001.
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