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In the Bhaishajya Kalpana domain, medication preparation and administration need artistry with scientific precision. Among scholars, researchers, and Rasashastra students, Chakradutta is highly appreciated because it is an updated manual of traditional Ayurvedic medicine for the betterment of humankind. It was written by Acharya Chakrapanidutta in the 11th century and another name of this book is \"Chikitsa Sangraha,\". Vrnds\'sSiddhayoga is the main inspiration of this book, as the author acknowledges at the end of the book. Among the various Kalpanas, at its core lies Guggulu Kalpana i.e. Vati Kalpana made up of Guggulu, an oily latex named Niryasa, sourced from the Indian bdellium tree, scientifically named Commiphora mukul.Chakradutta, an eminent ancient Indian physician, adeptly employed various Kalpana (Pharmaceuticalpreparations), often utilizing guggulu as a key binding agent. Whether consumed alone or in combination with other medications, particularly in pill form. According to Chakradutta, it is a versatile herb that shows its efficacy in both medicinal (Udarroga, Inflammation, Arthritis, Medo roga(obesity), Gridhrasi, Sandhivata, Katigrah, Aamvata, Kasa, Kushtha, Krimiroga(Microbial infections),Prameha, Vrana(wounds),Vidradhi, Pandu, Apsamar, Austharoga, Skin disorders, Bhagandar, Asthi- Bhagna (fracture), Dislocation,AmlapittaandDhoopan yoga (all types ofJvar,Vranshotha(Abscess), Krimiroga, Durgandhitkarna, Vrishchikavish chikitsa, Baalgrahnashak).Its usage in Kalka formulations to treat Shothaand in churna for treating ailments like Amlapitta(acid reflux), highlights its diverse applications. Kwathformulations utilize Gugguluto address different health issues. Moreover, in this book, its incorporation into Taila (oil) and Ghrita (ghee) preparations enhances its therapeutic value further. This article will be further helpful in understanding the action of Guggulu in different diseases and its prominence in Strotovikaras underscores its broad-spectrum efficacy, validated by multiple studies.