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The chromone structural motif has been associated with a number of biological activities. Chromone derivatives have displayed interesting antibacterial, antiviral, anticancer, anti-inflammatory, antioxidant, etc...On the other hand This system is widely used in organic chemistry as an intermediate compound for the synthesis of numerous hetrocycles. Some derivatives of chromone were synthesized by 2-4-6-trihydroxyacetophenone. Structures of obtained chomones were were indentified by IR, 1H-NMR,13C-NMR spectra.