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Background: WHO has declared that the mosquito as ‘public enemy number one’. The traditional Hindu system of medicine that is ‘Ayurveda’ stresses the use of plant-based medicines, treatments and preventions. Objectives: The present study is a based on some plant extracts, which can be used for preparation of mosquito repellents. There are many hazardous effects of synthetic repellents are seen on our health. This work is particularly focused to create such repellents which contain only natural substances and have no hazardous side effects on the human health. Methods: The leaf extracts of Neem (Azadirachta indica), Tulsi (Ocimum sanctum), Rui (Calotropis gigantea), Durva grass (Cynodon dactylon), Ashoka (Saraca asoca) and additional to this Cow urine & cow dung, Neem oil, distilled water, wax and Whatmann filter paper-1 were used. By using these all, dhoop stick, extract cards etc. were prepared and their antimosquito activity and antibacterial activities are also studied. Results: The natural repellents prepared by using given methodology have satisfactory anti mosquito as well as antimicrobial potential. Conclusion: The study revealed that these mosquito repellents have no side effect on human health. Beside this, these repellents are very cheap and can be easily prepared by common man.