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Polyherbal formulations were developed by using five bioactive N-butanol fractionated extracts of Eclipta alba, Picrorhizakurroa(Rhizome), Terminaliachebula (fruits),Piper nigrum (fruits),Nigella sativa(seeds), Tribulusterristris(whole plant) Linn, treatment of liver disorders by exploiting the knowledge of traditional system of medicine and evaluated for hepatoprotective activity using acute liver toxicity models of paracetamol,ccl4, ethanol, isoniazide induced liver damage in rats. Major active fractions were isolated by solvent fractionation and quantified by column chromatographic method. Two polyherbal tablet formulations were developed by the wet granulation method using microcrystalline cellulose, aerosil and other excipients and subjected for physicochemical evaluation to assess physical stability followed by pharmacological screening. The prepared tablets were finally subjected to stability testing to assess its shelf-life. The rats were monitored for change in liver morphology, biochemical parameters for polyherbal tablet formulation at 50 mg/kg and polyherbal tablet formulation at 100 mg/kg. Both formulations showed significant hepatoprotective activity. The histological studies were also support the biochemical parameters. From the results of biochemical analysis and histopathological studies, Biochemical marker showed improved results for polyherbal tablet formulation at 100 mg/kg. Polyherbal tablet formulation contains a potent hepatoprotective agent suggested to be a butanol fraction concentrated in polyherbal formulation which may find clinical application in amelioration of paracetamol, ethanol, ccl4, isoniazide induced liver damage.

According to the International Association for the Study of Pain, inflammation is the tissue\'s immunologic reaction to injury and is characterised by swelling, fluid buildup, and the mobilisation of white blood cells and antibodies. Natural treatments made from plants are called herbal medicines. Instead of eliciting a single molecule that interacts with a single target, they cause a coordinated pharmacological intervention of numerous compounds that interact with multiple targets. Using extracts of Curcuma amada, Piper nigrum, and Lodhra (Symplocos racemosa), menthol, and capsaicin, ten batches of polyherbal gel formulations were created. Formulations F1 through F5 were made with Carbopol 934, and Formulations F6 through F10 were made with HPMC K4M as the gelling agent. The developed formulations were assessed using a range of gel evaluation criteria, including pH determination and physical examination. Measurement of viscosity, washability, extrudability, spreadability, and in vitro diffusion studies. Spreadability of Formulation F2 was good, at 32.48±0.65 g/cm/sec. It was discovered that spreadability decreased when gelling agent concentrations (Carbopol 934 and HPMC K4M) increased. It was discovered that the extrudability of every polyherbal gel formulation ranged from 73.16% to 95.37%. The percentage of medication diffusion decreased as gelling agent concentration increased, according to the results. When compared to polyherbal formulations made with HPMC K4M, it was discovered that the components of formulations made with carbopol 934 were released more readily. The polyphenol content of the gel formulation is responsible for its in vitro anti-inflammatory effect. The stability of the F2 formulation was discovered. The developed formulation must be expanded on a pilot scale, and clinical studies are required to implement the successful introduction of a topical gel formulation including polyherbals for pain relief.