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Tyrosine kinase inhibitors (TKIs) have emerged as a novel cancer therapy for patients with poorly differentiated, anaplastic or medullary carcinomas unresponsive to conventional treatments. The association between fasting mimicking diets and TKIs has been explored with encouraging results showing a better response with less side effects due to TKI toxicity. Here we reportthe role of fasting in reducing cell survival and in potentiating the anticancer activity of TKIs (Lenvatinib, Sorafenib, Vandetanib and Cabozatinib) in cultured medullary, follicular, papillary and anaplastic thyroid cancer cells. In particular, fast mimicking diet reduced cell growth in all cell types but potentiated the anticancer activity of TKIs only in follicular, medullary and TPC1 thyroid cells. TKIs significantly reduced ERK1-2 activation after 1 h in all cell types. Prolonged exposure to TKIs resulted in an improvement of ERK1-2 phosphorylation which was inhibited in the presence of starvation. We demonstrated thyroid cancer cell susceptibility to fasting and validated its role in potentiating anticancer activity of TKIs by strengthening ERK1/2 signalling inhibition.

Nurses are health care professionals whose duty it is to protect patients from acquiring infections while hospitalized or while in a health care setup. By maintaining an infection-free environment, the patient’s recovery will be promoted and high-quality nursing care will be delivered. Aims and Objectives: The aim of the study was to determine the knowledge, attitudes, and practices of nurses regarding infection prevention and control. Material and Methods: A quantitative descriptive study was conducted at a tertiary hospital in Multan. Stratified random sampling was performed. Result and Conclusion: A total of n= 196 nurses of all categories were recruited in the study. Most of the participants were female; 84.7% (n= 166) while 15.3 % (n= 30) were male. The majority of participants had good knowledge of infection prevention and control with the mean score of 83.21. The attitude towards infection prevention and control was good with a mean score of 81.37. The practice in infection prevention and control was poor with a mean score of 48.88. Based on the findings of the current study, it can be concluded that, despite performing well in knowledge and showing a positive attitude towards infection prevention and control, nurses had unsatisfactory practice levels regarding infection prevention and control, exposing the pat1ients to infection-related diseases.

Acute viral hemorrhagic fever, known as Lassa, was first identified in 1969 in the town of Lassa, Borno State, Nigeria. Lassa is located in the valley of the Yeseram River near the southern end of Lake Chad. Three weeks after being infected with Lassa virus, patients feel sick. Pathogenesis is associated with immunosuppression, uncontrolled viral replication and host response, and infection does not cause lytic damage. Lassa viruses disable the host\\\'s immune system in several ways. The typical endosomal trafficking pathway essential for innate immune system recognition is bypassed. The most useful way for diagnosis is polymerase chain reaction (PCR) from blood. Sensitivity was reported as 79 % on the first day of hospitalization, increasing to 100 % on the third day. One of the most effective approaches to contain the spread of Lassa fever in endemic areas is to improve community cleanliness.

Lassa fever is a zoonotic disease caused by Lassa virus, which is a single-stranded RNA virus. Even though the virus was first described in the 1950s, it was not identified until 19691 and was subsequently named after a town in the present Borno state of Nigeria where the first case of the disease was recorded. The primary host of Lassa virus is a rodent of the genus. Mastomys, also referred to as ‘multimammate rat’. Once infected, Mastomys rats do not become ill but can shed the virus in their urine and faeces. Humans become infected from contact with the urine and faeces of infected rats. The infection can also occur in the process of hunting and processing rats for consumption. The virus is spread between humans through direct contact with blood, urine, faeces or other secretions from the infected person. As the world becomes increasingly connected, viral diseases, such as Lassa fever, once endemic to a region can be easily transmitted to other parts of the world, thus increasing the likelihood of a global pandemic. To reduce the probabilities of such events playing out, deliberate and concerted efforts must be applied towards both understanding Lassa fever and limiting infection rates. Therefore, measures that are limited in keeping of rodent out of homes and food supplies, as well as maintaining effective personal hygiene should be employed. Gloves, face masks, laboratory coats, and goggles are advised while in contact with an infected person.

In Uganda, hospital acquired pneumonia is the leading infection acquired from hospitals accounting for 33.3% of all hospital acquired infections. The purpose of this study was to explore knowledge and practices of nurses at Ishaka Adventist hospital on prevention of hospital acquired pneumonia. A quantitative cross sectional using a questionnaire assessed 44 nurses from Ishaka Adventist Hospital using convenient sampling method. Data obtained was analyzed using SPSS version 20.0 ad presented in tables and figures. Results of the study found that 41(93%) of nurses had heard about prevention of HAP prevention, 8(44%) of nurses did not know that suctioning catheters for very sick patients are supposed to be used once to prevent HAP, 21(51.2%) of nurses knew recovery position as safer positions for nursing very sick patients in order to prevent developing HAP 30(73.2) of nurses knew cough as early warning sign HAP, 28(68.2%) of nurses knew prophylaxis for Hap prevention 40(97.6%) of nurses knew aseptic techniques as precautions necessary for HAP prevention. 30(75%) of nurses hand washed to patient to prevent HAP, 39(97.5%) never avoided giving their HAP high risk patients PPIs, 35(87.5%) sterilized all instruments used while caring for very sick and other HAP high risk patients to prevent HAP, 36(90%) did not do oral care using salt/chrolohexidine for HAP prevention and 40(100%) of nurses who never practices rotational therapy for very sick and bedridden patients for HAP prevention. In conclusion, the knowledge on HAP prevention was poor as well as HAP prevention practices.

Fire is a visible effect of the process of combustion as a special type of chemical reaction which occurs when oxygen in the atmosphere reacts with some sort of fuel to bring out flame.This review research extensively detailed the causes, preventive and protective measure to be taken to curb fire outbreak in the society. This showed that the best way to avoid fire outbreak is by adopting preventive and protective measure which includes avoidance of using phone in the kitchen,fueling generator when it is ON, smoking in flammable prone zone, gas leakage and so on. This paper will guide home users and fire preventive software designers to be aware of the things to be incurred or put in consideration when managing/designing/ implementing a device that can prevent or control fire outbreak. This research review will be of important to the world as it serves as a guide on fire outbreak causes and simple ways to prevent it both manually and automatically.

Early Infant Diagnosis (EID) plays a crucial role in ensuring a HIV-free start for newborns born to HIV-positive mothers. This review highlights the significance of EID in pediatric HIV care, emphasizing its role in timely identification of HIV infection, prevention of morbidity and mortality, facilitation of Prevention of Mother-to-Child Transmission (PMTCT) programs, reduction of HIV transmission, and promotion of long-term health outcomes. Despite its importance, EID faces challenges such as limited access to testing services and logistical constraints. Addressing these challenges requires strengthening health systems and leveraging innovative approaches to expand access to EID services. Investing in EID programs is essential for achieving global HIV elimination targets and advancing towards an AIDS-free generation.