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Brucellosis is a zoonotic disease mainly acquired through consumption of infected animal products such as milk and meat. It is one of the leading zoonotic diseases and is a serious public health concern in endemic areas.Specifically, the review aimed at updating the burden of brucellosis in Uganda.Different research engines were utilised in writing this paper such as web of science, Pubmed Central, Scopus, Medline, Google Scholar, Researchgate, Academia Edu, etc.Prevalence of Brucellosis is low in Uganda. Being a Butcher, Milking, drinking raw milk are highly associated with brucellosis. The commonly used antimicrobials to manage Brucellosis are highly active against brucella except rifampicin. Brucella infection should be among the plan for treatment of febrile illness alongside malaria and Typhoid. Support is needed to allow more analysis on isolates such as sequencing and phylogeny analysis to learn more on the management of Brucella Epidemiology and ecology in this region.