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The human scalp is susceptible to microbial build-up if not thoroughly and frequently washed with the appropriate cleansing agent such as shampoo. Shampoo is a fast-moving commodity for hair care that is used to get rid of contaminants such as dandruff, oils, grime, skin fragments, and other contaminants that slowly accumulate in the hair. The purpose of shampoo is to remove the undesirable buildup without extracting too much sebum to leave hair unmanageable. The chemicals in shampoo may harm the healthy microorganisms in our hair. In this study, the antibacterial efficacy of the most popular shampoo products is investigated. In order to evaluate the quality in terms of biocampatibility four different brands of shampoo for both regular shampoo and anti-dandruff shampoo were selected. The present study focussed on In-vitro antibacterial activity of commonly used shampoos. The samples selected were namely Himalaya, Meera, Dove, Pantene. They were examined for in-vitro antibacterial activity for bio-compatibility. The compound were analyzed for five gram positive bacterias such as Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, Cutibacterium, Candida albicans, gram negative bacteria Salmonella typhi and One fungi species named as Microsporum canis. The current study highlighted the anti-microbial assay of the commercially available shampoo products based on the well diffusion method. The biocompatibility of the products with seven different microbes were assessed. The experiment results have brought Interesting insights and helped to identify the safe products for dermatological relevance.

According to the International Association for the Study of Pain, inflammation is the tissue\'s immunologic reaction to injury and is characterised by swelling, fluid buildup, and the mobilisation of white blood cells and antibodies. Natural treatments made from plants are called herbal medicines. Instead of eliciting a single molecule that interacts with a single target, they cause a coordinated pharmacological intervention of numerous compounds that interact with multiple targets. Using extracts of Curcuma amada, Piper nigrum, and Lodhra (Symplocos racemosa), menthol, and capsaicin, ten batches of polyherbal gel formulations were created. Formulations F1 through F5 were made with Carbopol 934, and Formulations F6 through F10 were made with HPMC K4M as the gelling agent. The developed formulations were assessed using a range of gel evaluation criteria, including pH determination and physical examination. Measurement of viscosity, washability, extrudability, spreadability, and in vitro diffusion studies. Spreadability of Formulation F2 was good, at 32.48±0.65 g/cm/sec. It was discovered that spreadability decreased when gelling agent concentrations (Carbopol 934 and HPMC K4M) increased. It was discovered that the extrudability of every polyherbal gel formulation ranged from 73.16% to 95.37%. The percentage of medication diffusion decreased as gelling agent concentration increased, according to the results. When compared to polyherbal formulations made with HPMC K4M, it was discovered that the components of formulations made with carbopol 934 were released more readily. The polyphenol content of the gel formulation is responsible for its in vitro anti-inflammatory effect. The stability of the F2 formulation was discovered. The developed formulation must be expanded on a pilot scale, and clinical studies are required to implement the successful introduction of a topical gel formulation including polyherbals for pain relief.