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A total number of 250 one day-old broiler cobb500™ chicks were used to study effect of nano silver on performance of growth and some physiological parameters of broiler chicks in the diet or drinking water under south Sinai condition. Chicks were randomly distributed into 5 equal experimental treatments of 50 chicks each. Every treatment was sub-divided into 5 replicates (10 chicks/ replicates), the chicks were housed in cages from hatch up to 5 weeks of age. The first group was fed the basal diet as a control(C), while, the other four treatments were fed diets containing either 10 and 15 mg/liter of drinking water silver (Ag NPs) for T1 and T2, respectively, while T3 and T4 treatments were fed on 10 and 15 mg / kg diets, respectively. Results obtained could be summarized as follows: Live body weight was increased significantly varied (P<0.01) among the different experimental treatment with the Ag NPs in drinking water and diets more than that of the control diet. Live body weight was improved with the Ag NPs level in the drinking water at 10 mg/ liter of drinking water and 10 mg/kg diets. Feed conversion ratio was better when given via the drinking water. Results on different growing period for clicks recorded significant differences in all carcass traits. Body weight and feed consumption were significant increase, synchronous with the increasing in thyroid hormone, total protein, IGG and AIGM. The same enhanced were in decrease of total lipid and cholesterol in blood, synchronous with the increasing in thyroid hormone; total protein; IGG and AIGM. The same enhanced were in decrease of total lipid and cholesterol in blood. The effect of the material used harmless to the birds and it is clear from the liver and kidney function means no side effects of the substance under study. In conclusion, View, the nano form of silver with 10 ppm/ liter of drinking water can be used on growth improve or some physiological parameters for broiler chicks under semiarid condition.